'We didn't want to include a much larger dose, because we wanted to avoid potential adverse effects or cardiovascular effects that can result from higher doses of THC.'Participants attended two four-hour sessions at the University of Chicago, five days apart. The medicine has the psycho-active elements of marijuana, THC, removed. The drug offers hope for thousands of children living with untreatable epilepsy.
Cannabidiol halved the seizures suffered by children with a severe form of the condition called Dravet syndrome.
Researchers in Chicago split 42 people into three groups, and gave them each a batch of THC capsules - one equivalent to a couple of puffs, one equivalent to half a joint, and one a placebo.
THC, or tetrahydrocannabinol, is the psychoactive compound in cannabis which makes users feel 'high'.
Participants who received 12.5 milligrams of THC before the two tasks reported greater negative mood before and throughout the task, and were more likely to rate the psychosocial task as 'challenging' and 'threatening' beforehand.
Participants who received this dose also had more pauses during the mock interview compared to those in the placebo group.
There were no significant differences in participants' blood pressure, heart rate or cortisol levels—before, during or after the doses or the tasks.'Our findings provide some support for the common claim that cannabis is used to reduce stress and relieve tension and anxiety,' Childs said.